2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-109002R
    Apararenone (Standard) 945966-46-1
    Apararenone (Standard) is the analytical standard of Apararenone (HY-109002). This product is intended for research and analytical applications. Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.
    Apararenone (Standard)
  • HY-109010R
    Poseltinib (Standard) 1353552-97-2
    Poseltinib (Standard) is the analytical standard of Poseltinib (HY-109010). This product is intended for research and analytical applications. Poseltinib (HM71224) is an orally active, selective, irreversible small molecule Bruton tyrosine Kinase (BTK) inhibitor. With an IC50 of 1.95 nM. Poseltinib effectively inhibits the signaling mediated by B cell receptors (BCR), Fc receptors (FcR), and Toll-like receptors (TLR). Poseltinib has anti-inflammatory activity and can be used in the research of rheumatoid arthritis.
    Poseltinib (Standard)
  • HY-109018R
    Velagliflozin (Standard) 946525-65-1
    Velagliflozin (Standard) is the analytical standard of Velagliflozin (HY-109018). This product is intended for research and analytical applications. Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity.
    Velagliflozin (Standard)
  • HY-109032R
    Firuglipel (Standard) 1371591-51-3
    Firuglipel (Standard) is the analytical standard of Firuglipel (HY-109032). This product is intended for research and analytical applications. Firuglipel (DS-8500a) is an orally available, potent and selective GPR119 agonist.
    Firuglipel (Standard)
  • HY-109039R
    Praliciguat (Standard) 1628730-49-3
    Praliciguat (Standard) is the analytical standard of Praliciguat (HY-109039). This product is intended for research and analytical applications. Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase (sGC) activator. Praliciguat can increases cGMP via the nitric oxide (NO)-sGC pathway. Praliciguat can inhibit the expression of proinflammatory cytoKines and inhibit apoptosis. Praliciguat can promote vasodilation. Praliciguat can be used for the researches of metabolic disease and cardiovascular disease, such as hypertension, diabetes and heart failure.
    Praliciguat (Standard)
  • HY-109061R
    Lazertinib (Standard) 1903008-80-9
    Lazertinib (Standard) is the analytical standard of Lazertinib (HY-109061). This product is intended for research and analytical applications. Lazertinib (YH25448) is a potent, selective, CNS-penetrant, orally available and irreversible EGFR tyrosine Kinase inhibitor, exhibiting high selectivity for activating (EGFRm) and T790M resistance mutations. Lazertinib inhibits phosphorylation of EGFR, AKT and ERK, leading to apoptosis and suppression of tumor growth in mouse H1975-luc brain metastasis xenograft models. Lazertinib can be used in the study of non-small cell lung cancer.
    Lazertinib (Standard)
  • HY-109079R
    Abeprazan (Standard) 1902954-60-2 98%
    Abeprazan (Standard) is the analytical standard of Abeprazan (HY-109079). This product is intended for research and analytical applications. Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.
    Abeprazan (Standard)
  • HY-109092R
    Licogliflozin (Standard) 1291094-73-9 98%
    Licogliflozin (Standard) is the analytical standard of Licogliflozin (HY-109092). This product is intended for research and analytical applications. Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor.
    Licogliflozin (Standard)
  • HY-109120R
    Odevixibat (Standard) 501692-44-0 98%
    Odevixibat (Standard) is the analytical standard of Odevixibat. This product is intended for research and analytical applications. Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis.
    Odevixibat (Standard)
  • HY-109134R
    Pizuglanstat (Standard) 1244967-98-3 98%
    Pizuglanstat (Standard) is the analytical standard of Pizuglanstat (HY-109134). This product is intended for research and analytical applications. Pizuglanstat (Compound 3; TAS-205 free base) is an orally active prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthase. Pizuglanstat inhibits the synthesis of PGD2. Pizuglanstat improves experimental allergic rhinitis. Pizuglanstat can be used in the study of muscle regenerative diseases such as muscular dystrophy.
    Pizuglanstat (Standard)
  • HY-109136R
    Runcaciguat (Standard) 1402936-61-1 98%
    Runcaciguat (Standard) is the analytical standard of Runcaciguat (HY-109136). This product is intended for research and analytical applications. Runcaciguat (BAY 1101042) is a selective, orally active, allosteric activator of soluble guanylate cyclase (sGC) that specifically targets its oxidized and heme-free form. Runcaciguat binds to sGC in a histidine-dependent manner and restores cyclic guanosine monophosphate (cGMP) production under oxidative stress, independent of nitric oxide (NO) or heme. Runcaciguat exhibits renoprotective and cardioprotective activities, such as reduced proteinuria and improved renal function. Runcaciguat is primarily being studied in chronic Kidney disease (CKd) associated with hypertension, diabetes, and metabolic disorders, as well as potential cardiovascular indications such as heart failure with preserved ejection fraction (HFpEF).
    Runcaciguat (Standard)
  • HY-109144R
    Enavogliflozin (Standard) 1415472-28-4 98%
    Enavogliflozin (Standard) is the analytical standard of Enavogliflozin (HY-109144). This product is intended for research and analytical applications. Enavogliflozin (DWP-16001), an antidiabetic agent, is an orally active, best-in-class and selective sodium-glucose cotransporter-2 (SGLT-2) inhibitor.
    Enavogliflozin (Standard)
  • HY-109174R
    Fosciclopirox (Standard) 1380539-06-9 98%
    Fosciclopirox (Standard) is the analytical standard of Fosciclopirox (HY-109174). This product is intended for research and analytical applications. Fosciclopirox (CPX-POM) suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies.
    Fosciclopirox (Standard)
  • HY-109500R
    Masoprocol (Standard) 27686-84-6 98%
    Masoprocol (Standard) is the analytical standard of Masoprocol. This product is intended for research and analytical applications. Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes.
    Masoprocol (Standard)
  • HY-109538R
    Secretin (swine) (Standard) 17034-35-4
    Secretin (swine) (Standard) is the analytical standard of Secretin (swine). This product is intended for research and analytical applications. Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.
    Secretin (swine) (Standard)
  • HY-109542R
    Cyclopenthiazide (Standard) 742-20-1
    Cyclopenthiazide (Standard) is the analytical standard of Cyclopenthiazide. This product is intended for research and analytical applications. Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney.
    Cyclopenthiazide (Standard)
  • HY-109567R
    Gemcabene (Standard) 183293-82-5 98%
    Gemcabene (Standard) is the analytical standard of Gemcabene. This product is intended for research and analytical applications. Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity.
    Gemcabene (Standard)
  • HY-110255C
    AZD 2066 sulfate 934282-57-2 98%
    AZD 2066 sulfate is a mGluR5 antagonist and also the sulfate salt of 4-(5-{(1R)-1-ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl) pyridine. AZD 2066 sulfate is used in research on various diseases including Alzheimer's disease, autism, and obesity.
    AZD 2066 sulfate
  • HY-111151R
    AR-9281 (Standard) 913548-29-5 98%
    AR-9281 (Standard) is the analytical standard of AR-9281. This product is intended for research and analytical applications. AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes.
    AR-9281 (Standard)
  • HY-111345A
    Epaminurad hydrochloride 1198153-46-6 98%
    Epaminurad (UR-1102) hydrochloride is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a Ki of 0.057 μM. Epaminurad hydrochloride quite modestly inhibits OAT1 and OAT3 (organic anion transporter). Epaminurad hydrochloride is a uricosuric agent. Epaminurad hydrochloride can be used for gout and hyperuricemia research.
    Epaminurad hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity